PATENTS
- 4 patents on molecules:
Hydrosoluble hydroxy-bisphosphonic derivatives of doxorubicine. Egorov, Maxim; Goujon, Jean-Yves; Le Bot, Ronan; David, Emmanuelle. PCT Int. Appl. (2016), WO 2016079327 A1.
Bifunctional hydroxy-bisphosphonic acid derivatives. Egorov, Maxim; Goujon, Jean-Yves; Le Bot, Ronan. PCT Int. Appl. (2012), WO 2012130911 A1 20121004.
Preparation of fumagillol derivatives useful for the treatment or prevention of bone tumors. Egorov, Maxim; Le Bot, Ronan; Petit, Fabien; Grovel, Olivier; Pouchus, Yves Francois; Vansteelandt, Marieke. PCT Int. Appl. (2012), WO 2012130906 A1 20121004.
Hydroxy-bisphosphonic acid derivatives as vectors for therapeutic and diagnostic targeting of bone tissue. Egorov, Maxim; Fortun, Yannick; Heymann, Dominique; Lebreton, Jacques; Mathe, Monique; Padrines, Marc; Redini, Francoise. PCT Int. Appl. (2009), WO 2009083614 A1 20090709.
- 1 patent on process:
Improved process for preparation of 1-hydroxy-1,1-diphosphonic acids and salts by addition of tris(trimethylsilyl) phosphite to carboxylic acids, activated by catecholborane. Egorov, Maxim; Fortun, Yannick; Heymann, Dominique; Lebreton, Jacques; Mathe, Monique; Padrines, Marc; Redini, Francoise. PCT Int. Appl. (2009), WO 2009083613 A1 20090709.
PUBLICATIONS
- Phase I dose escalation study of 12b80 (hydroxybisphosphonate linked doxorubicin) in naturally occurring osteosarcoma. Pierre Boyé, Emmanuelle David, François Serres, Quentin Pascal, Franck Floch, Kévyn Geeraert, Virginie Coste, Laurent Marescaux, Sébastien Cagnol, Jean-Yves Goujon, Maxim Egorov, Ronan Le Bot and Dominique Tierny. Oncotarget (2020), 11:4281-4292.
- 12b80 − Hydroxybisphosphonate Linked Doxorubicin: Bone Targeted Strategy for Treatment of Osteosarcoma. David, Emmanuelle; Cagnol, Sebastien; Goujon, Jean-Yves; Egorov, Maxim; Taurelle, Julien; Benesteau, Charlene; Morandeau, Laetitia; Moal, Christelle; Sicard, Marie; Pairel, Samuel; Heymann, Dominique; Redini, Françoise; Gouin, François; Le Bot, Ronan. Bioconjugate Chemistry Scientific journal (2019), 2019 Jun 19;30(6):1665-1676. doi: 10.1021/acs.bioconjchem.9b00210. Epub 2019 May 10
- A One‐Pot Synthesis of 1‐Hydroxy‐1,1‐bis(phosphonic acid)s Starting from the Corresponding Carboxylic Acids.. Egorov, Maxim; Aoun, Sameh; Padrines, Marc; Redini, Francoise; Heymann, Dominique; Lebreton, Jacques; Mathe-Allainmat, Monique. European Journal of Organic Chemistry (2011), 2011(35), 7148-7154, S7148/1-S7148/55.
- Blanchet E, Vansteelandt M, Le Bot R, Egorov M, Guitton Y, Pouchus YF, Grovel O. Synthesis and antiproliferative activity of ligerin and new fumagillin analogs against osteosarcoma. Eur J Med Chem. 2014 May 22;79:244-50. doi: 10.1016/j.ejmech.2014.04.012. Epub 2014 Apr 5.
- Monderer D, Luseau A, Bellec A, David E, Ponsolle S, Saiagh S, Bercegeay S, Piloquet P, Denis MG, Lodé L, Rédini F, Biger M, Heymann D, Heymann MF, Le Bot R, Gouin F, Blanchard F. New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance. Lab Invest. 2013 Oct;93(10):1100-14. doi: 10.1038/labinvest.2013.101. Epub 2013 Aug 19.
- Vansteelandt M, Blanchet E, Egorov M, Petit F, Toupet L, Bondon A, Monteau F, Le Bizec B, Thomas OP, Pouchus YF, Le Bot R, Grovel O. Ligerin, an antiproliferative chlorinated sesquiterpenoid from a marine-derived Penicillium strain. J Nat Prod. 2013 Feb 22;76(2):297-301. doi: 10.1021/np3007364. Epub 2013 Jan 29.
- Daubine F, Le Bot R, Márquez M, Nilsson S, Schröder T, Holmberg AR.Treatment of bone metastasis in prostate cancer: efficacy of a novel polybisphosphonate. Anticancer Res. 2011 Dec;31(12):4141-5
